NIH Director’s Wednesday Afternoon Lecture Series
From the 17th through the 19th century, beautifully artistic micrographs of living specimens were inextricably linked to biological discovery. However, for much of the 20th century, optical microscopy took a back seat to the powerful new fields of genetics and biochemistry. Starting in the 1980s, the tables started to turn again, thanks to the widespread availability of computers, lasers, sensitive detectors, and fluorescence labeling techniques.
Research in the Booker Lab focuses on understanding how Nature harnesses the power of radicals to effect kinetically challenging enzymatic reactions, many of which are critical to proper cellular functioning. Much of the lab’s work has centered around the enzymatic use of S-adenosylmethionine and iron-sulfur clusters to generate a 5’-deoxyadenosyl 5’-radical, used as a key intermediate by members of the radical S-adenosylmethionine (SAM) superfamily to catalyze over 60 different reaction types.
Dr. Pfeiffer studies RNA virus evolution, dissemination, pathogenesis, and transmission. Her recent interests include examining the impact of intestinal microbiota on enteric virus infections. Her lab has determined that intestinal bacteria promote replication of several enteric viruses and ongoing work is examining mechanisms and consequences of bacteria-virus interactions.
The page was last updated on Tuesday, January 23, 2018 - 8:42am