NIH Director’s Wednesday Afternoon Lecture Series
Dr. Parkhurst's lecture has been rescheduled to December 2, 2020.
RESCHEDULED FOR JAN. 27, 2021 – Black Spot, Black Death, Black Pearl: the Tales of Bacterial Effectors
Dr. Orth's lecture has been rescheduled to January 27, 2021.
The Orth lab is interested in elucidation the activity of virulence factors from pathogenic bacteria so that we can gain novel molecular insight into eukaryotic signaling systems.
We study ATP-binding cassette (ABC) transporters, a diverse group of membrane proteins integral to almost every biological process. In prokaryotes, these proteins are critical for survival. In humans, ABC transporters make up one of the largest gene families, and more than a dozen genetic diseases have been traced to ABC transporter defects. ABC transporters are also central to multidrug resistance in many pathogenic bacteria and in tumor cells.
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