Did you remember to take out the trash? Your cells sure did!
Dr. Cuervo’s group is interested in understanding how altered proteins can be eliminated from the cells through the lysosomal system (autophagy) and how malfunction of autophagy in aging is linked to neurodegenerative diseases. More recently, her group has identified alterations in the autophagic system in cancer biology and has engaged in a research program focused in further exploring this interaction through collaborative efforts with clinical oncology departments.
Autophagy is an essential catabolic cellular process that assures the maintenance of the cellular energetic balance as wells as an efficient removal of any intracellular damaged structure. In this talk, Dr. Cuervo will focus on selective forms of autophagy, and describe her lab’s recent advances on the identification of new molecular effectors and regulators for these pathways, the physiological role, and their changes in aging and age-related metabolic disorders and neurodegenerative diseases such as Parkinson, Alzheimer and Huntington disease. She will also present some of her lab’s genetic and chemical efforts to modulate autophagy to enhance the cellular defense against stress.
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