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Human organs on chips and programmable nanotherapeutics

June 18, 2014
Donald E. Ingber, M.D., Ph.D., Wyss Institute for Biologically Inspired Engineering at Harvard University

Dr. Ingber will describe the work that his group has been carrying out in the Biomimetic Microsystems and Programmable Nanomaterials platforms at the Wyss Institute, as well as their new model for innovation, collaboration, and technology translation. The goal of the first platform is to engineer human “Organs-on-Chips”: microchips lined by living human cells created with microfabrication techniques that recapitulate organ-level functions as a way to replace animal testing for drug development. Dr.

Typhoid toxin: a window into the unique biology of Salmonella typhi

June 25, 2014
Jorge E. Galán, Ph.D., D.V.M., Yale University School of Medicine

Dr. Galán’s studies have led to the identification of the first pathogenicity island in Salmonella and the discovery and characterization of a type III protein secretion system (TTSS) in these bacteria, a specialized organelle that mediates the transfer of bacterial proteins into host cells. In a joint effort with Dr. Aizawa, his laboratory discovered the “needle complex”, a bacterial organelle that constitutes the core component of TTSSs.

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