Dysregulation of the immune system and host-microbiota interaction has been associated with the development of a variety of inflammatory as well as metabolic diseases such as obesity and diabetes. Recent studies in Dr. Flavell's laboratory have elucidated the important function of inflammasomes as steady-state sensors and regulators of the gut microbiota. Mice with a disrupted inflammasome pathway have been shown to develop a colitogenic microbial community, which results in exacerbation of chemical-induced colitis and diet-induced steatohepatitis, obesity and type 2 diabetes.
This year's annual NIH J. Edward Rall Cultural Lecture features Dr. Sanjay Gupta, an Emmy Award-winning journalist and chief medical correspondent for CNN. Dr. Gupta is a successful practicing neurosurgeon and a member of the American College of Surgeons, the American Association of Neurological Surgeons, and the Congress of Neurological Surgeons. His talk is is entitled "Medicine and the Media: A morning with Sanjay Gupta, M.D."
This lecture will be rescheduled. Check back soon for more information.
The underlying molecular basis has been determined for more than 2,000 inherited monogenic disorders, of which at least 20 percent have cutaneous manifestations. The explosion of knowledge about genetics and genetic disease during the past 20 years has helped us to understand how gene changes translate into clinical manifestations.
The Virgin lab issues at the interface between virology and immunology, working from the hypothesis that viruses manipulate the immune response using immunoevasive gene products as the immune response attempts to eradicate the virus. Please see the informative and amusing animated video at http://pathology.wustl.edu/labs/virgin.
Dr. Reese directs an NIH multi-million dollar research laboratory group studying the bio-molecular mechanisms of diabetes-induced birth defects. His laboratory has determined that there are specific cytoarchitectural changes at the epithelial level of the cell associated with these anomalies.
My lab has used genetic strategies to generate cultured cells and mice with Notch receptors that carry no fucose, or only O-fucose, or O-fucose with GlcNAc transferred by a single Fringe enzyme, to identify roles for O-fucose and each Fringe glycosyltransferase in embryonic development and in T and B cell development.
Dr. Garber conducts research in clinical cancer genetics, with a special focus in the genetics of breast cancer. She has played a major role in the development of national guidelines in cancer genetics. Dr. Garber is also a leader in research into the characteristics and treatment of triple negative or basal-like breast cancer, the most common form in women with BRCA1 mutations.
Dr. Page's laboratory seeks to understand fundamental differences between males and females in health and disease, both within and beyond the reproductive tract. Most recently, the Page lab discovered that XY and XX sex chromosomes account for subtle differences in the molecular biology of male and female cells and tissues throughout the body. These findings emerged from the lab’s comparative genomic and evolutionary studies of the sex chromosomes of humans, other mammals, and birds.
The neural crest is a population of multipotent, migratory stem/progenitor cells that forms at the border of neural and non-neural ectoderm in vertebrate embryos. These cells then migrate from the neural tube along defined pathways, populate numerous sites, and differentiate into diverse cells types including melanocytes, sensory and autonomic neurons, and the craniofacial skeleton. However, neural crest populations differ along the neural axis with respect to migration pathways and derivatives.
The page was last updated on Monday, November 24, 2014 - 5:47pm