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From protein folding to cognition: a serendipitous path of discovery

Wednesday, April 19, 2017 - 3:00pm to 4:00pm

Speaker

Peter Walter, Ph.D.
Principal Investigator
University of California, San Francisco

Summary

A screen for small molecule modulators of the unfolded protein response yielded ISRIB, a drug-like compound that with high efficacy renders cells insensitive to translational inhibition by phosphorylation of eIF2. ISRIB is an activator of eIF2B, eIF2’s guanine nucleotide exchange factor, and a cognitive enhancer in rodents, significantly improving long-term memory of wild-type animals in behavioral assays.


The page was last updated on Thursday, April 13, 2017 - 4:35pm