Gut reactions: host microbiome interactions in the intestine in health and disease
The gastrointestinal tract is home to a large number and vast array of bacteria that play an important role in nutrition, immune-system development, and host defense. In inflammatory bowel disease there is a breakdown in this mutualistic relationship resulting in aberrant inflammatory responses to intestinal bacteria. Studies in model systems indicate that intestinal homeostasis is an active process involving a delicate balance between effector and immune suppressive pathways. For her presentation, Dr. Powrie will discuss bacterial pathways that promote intestinal homeostasis and host defense, and how these may be harnessed therapeutically.
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