The VHL tumor suppressor: insights into oxygen sensing, cancer metabolism, and drugging the undruggable
A Howard Hughes Medical Investigator since 1998, Dr. Kaelin's research seeks to understand how, mechanistically, mutations affecting tumor-suppressor genes cause cancer. His long-term goal is to lay the foundation for new anticancer therapies based on the biochemical functions of tumor suppressor proteins. His work on the VHL protein helped to motivate the eventual successful clinical testing of VEGF inhibitors for the treatment of kidney cancer.
Thomas Südhof is interested in how synapses form and function in the developing and adult brain. His work focuses on the role of synaptic cell-adhesion molecules in establishing synapses and shaping their properties, on pre- and postsynaptic mechanisms of membrane traffic, and on impairments in synapse formation and synaptic function in neuropsychiatric and neurodegenerative disorders.
Dr. Abel's current research interests focus on elucidating the molecular mechanisms leading to cardiac dysfunction in diabetes and the regulation of myocardial growth and metabolism by insulin signaling.
Dr. Passagué's research investigates the biology of blood-forming hematopoietic stem cells in normal and deregulated contexts such as development of hematological malignancies and physiological aging.
Dr. Barnes' research focus is on racial disparities in chronic diseases of aging, with a particular focus on Alzheimer’s disease and cognitive decline.
For decades, the mitochondria have been primarily viewed as biosynthetic and bioenergetic organelles generating metabolites for the production of macromolecules and ATP, respectively. Our work has elucidated that mitochondria have a third distinct role whereby they release reactive oxygen species (ROS) and metabolites such as L-2-hydroxyglutarate to initiate physiological and pathological processes including hypoxic activation of HIFs, cellular differentiation, T cell activation and cancer cell proliferation. Thus, mitochondria function as signaling organelles.
Fiona Powrie is interested in the intestinal immune system’s ability to distinguish foreign microbes from the trillions of harmless bacteria that reside in our gut –and how this delicate balancing act breaks down in inflammatory bowel disease. Her work has identified suppressor ‘regulatory T cells’ that are crucial for gut homeostasis, as well as immune signals pivotal for chronic intestinal inflammation. She received the Louis Jeantet Prize for Medicine in 2012 and was elected a Fellow of the Royal Society in 2011.
The Herbert lab investigates cellular and molecular mechanisms responsible for the initiation of Type 2 immunity against gastrointestinal helminths and enteropathogenic bacteria. We are focused upon identification of novel cytokine/receptor interactions that regulate the cross-talk between epithelial and myeloid compartments leading to pathogen clearance and tissue repair.
Over the past ten years, we have investigated the developmental origin and homeostasis of macrophages and the related cell types monocytes and dendritic cells. These cells play a major role in development, homeostasis and diverse types of cancer and can either restrain or promote cancer progression and metastasis. The Geissmann lab is now building on previous work to investigate mechanisms by which tissue macrophages may control tissue growth and metabolism and whether these same mechanisms play a role in cancer initiation and development.
Research in the Subramaniam lab over the last decade has been guided by the vision that emerging tools in 3D electron microscopy hold great promise for imaging cells, viruses and protein complexes at high resolution in their native states, thus bridging a major gap in structural biology. In his talk, he will review examples of recent progress ranging from determination of protein structures at atomic resolution to imaging viruses, cells and tissue at nanometer resolution.
The page was last updated on Wednesday, January 3, 2018 - 12:38pm