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Current Lecture Season

RNA antics in viral drug resistance and host immunosuppression

March 3, 2021 - 3:00pm to 4:00pm
Karla Kirkegaard, Ph.D., Stanford University School of Medicine

The Kirkegaard laboratory deciphers the genetics of RNA viruses and their mammalian hosts, with the goal of suppressing drug resistance and excessive inflammation during viral infections.

CFTR, the Odd ABC Transporter Responsible for Cystic Fibrosis

April 28, 2021 - 3:00pm to 4:00pm
Jue Chen, Ph.D., The Rockefeller University

We study ATP-binding cassette (ABC) transporters, a diverse group of membrane proteins integral to almost every biological process. In prokaryotes, these proteins are critical for survival. In humans, ABC transporters make up one of the largest gene families, and more than a dozen genetic diseases have been traced to ABC transporter defects. ABC transporters are also central to multidrug resistance in many pathogenic bacteria and in tumor cells.

Droplets, droplets everywhere…cell organization by liquid-liquid phase separation

May 26, 2021 - 3:00pm to 4:00pm
Michael K. Rosen, Ph.D., UT Southwestern Medical Center

The Rosen lab seeks to understand the formation, regulation and functions of enigmatic, cellular compartments termed biomolecular condensates. These evolutionarily conserved structures concentrate diverse but specific groups of molecules without a surrounding membrane. Condensates appear to form through the physical process of liquid-liquid phase separation. Using a range of techniques, including biochemical reconstitution and in vitro and cellular microsopies, we investigate phase separation in both engineered and natural condensates. The former, in their simplified nature, enable

Casting the Net Wide: the Role of Neutrophils in Chronic Diseases

June 9, 2021 - 3:00pm to 4:00pm
Mariana J. Kaplan, M.D., National Institute of Arthritis and Musculoskeletal and Skin Diseases

Dr. Kaplan's research has focused on identifying mechanisms of immune dysregulation, organ damage and premature vascular disease in systemic autoimmunity. More specifically, she investigates how innate immunity (in particular, type I interferons and myeloid cells) promote end-organ damage in systemic lupus erythematosus, rheumatoid arthritis and other systemic autoimmune diseases.


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