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NIH Director’s Wednesday Afternoon Lecture Series

Accepting nominations for the 2022–2023 WALS season through January 21, 2022.

Watch lectures live at https://videocast.nih.gov at the time of the event.
Binge-watch the archives dating back more than 20 years at https://videocast.nih.gov/PastEvents?c=3.

Oh, one more thing…
Not at the NIH? Sign up for notices about each lecture.

Featured Lectures

Diabetes Health Disparities: Biology, Race, or Racism

September 29, 2021 - 3:00pm to 4:00pm

Sherita Hill Golden, M.D., John Hopkins Medicine

As a specialty, endocrinology has focused on biological contributors to disparities in diabetes, obesity and other endocrine disorders. Less attention has been paid, however, to the institutional racism inherent in our healthcare systems and social policies that lead to those biological risk factors.
Creating Healthy Longevity: A Basis for a Third Demographic Dividend for Society

October 6, 2021 - 3:00pm to 4:00pm

Margaret Pittman Lecture

Linda Fried, M.D. , Columbia University Medical Center

This lecture addresses the opportunities of our extended life span for individuals and society if health span is extended to approximate life span. It considers the range of health outcomes that would need to be prevented or delayed, and considers the possibilities to accomplish this. Dr. Fried will offer a perspective that increased health span combined with enabling the potential social capital of older adults could set the stage for a previously unimagined "Third Demographic Dividend" for societies.
Blood Stem Cell Clonality and the Niche

November 17, 2021 - 3:00pm to 4:00pm

Leonard Zon, M.D., Harvard Medical School

Dr. Zon will discuss two critical avenues of his current research: identifying the genes that direct stem cells to become cancers or to develop into more specialized blood or organ cells; and developing chemical or genetic suppressors to cure cancers and many other devastating diseases. In the past five years, his lab has collected more than 30 mutants affecting the hematopoietic system. Several represent excellent animal models of human disease.

Upcoming Lectures

Advancing Therapies for Neurofibromatosis Type 1 (NF1): Lessons Learned from Every Patient

December 8, 2021 - 3:00pm to 4:00pm

Astute Clinician Lecture

Brigitte Widemann, M.D., National Institutes of Health, National Cancer Institute

Dr. Brigitte Widemann is a pediatric oncologist with the primary interest of developing effective therapies for children and adults with genetic tumor predisposition syndromes, such as neurofibromatosis type 1 (NF1), and rare solid tumors through innovative clinical trial design. Dr. Widemann currently serves as the head of the Pharmacology & Experimental Therapeutics Section and as Chief of NCI’s Pediatric Oncology Branch. Anticancer drug discovery and development are moving towards a more rational and targeted approach.

Cytokine Signaling: The More Things Change, the More They Stay the Same

December 15, 2021 - 3:00pm to 4:00pm

William E. Paul Lecture

John O'Shea, M.D., National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH

Cytokines are critical for host defense but are also key factors in immune and inflammatory diseases. Innate and adaptive lymphocytes, including T cells, are important selective producers of cytokines, and it is through the production of these that immune responses work together to eliminate microbial pathogens. Host defense against pathogenic microorganisms requires this elegant means of communication between innate and adaptive arms of the immune system.