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Can you catch dementia? Insights and solutions from prion disease

Thursday, December 6, 2018 - 2:00pm to 3:00pm


John Collinge, M.D.
Professor of Neurology
University College London


Professor Collinge leads a highly multidisciplinary research unit dedicated to understanding prion diseases. Prions are notorious “protein-only” infectious agents devoid of genes which cause invariably fatal brain diseases following silent incubation periods which may span a human lifetime. The diseases can arise spontaneously, by infection or be inherited. Remarkably, prions are composed of a cloud of self-propagating assemblies of a misfolded cellular protein that can encode information, generate neurotoxicity and evolve and adapt in vivo. There are increasing parallels with Alzheimer’s disease and other neurodegenerative conditions involving brain deposition of polymers of misfolded proteins. His work focusses on molecular mechanisms of prion propagation, strain diversity and neurotoxicity and their wider relevance to commoner neurodegenerative diseases. He has a particular interest in therapeutics of prion and Alzheimer’s disease and he is developing both small molecule and immunotherapeutics.

The page was last updated on Monday, December 3, 2018 - 11:42am