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Casting the NET Wide: Neutrophils Shape Chronic Inflammatory Diseases

Wednesday, June 9, 2021 - 3:00pm to 4:00pm


Mariana J. Kaplan, M.D.
Senior Investigator
Chief, Systemic Autoimmunity Branch
Deputy Scientific Director
National Institute of Arthritis and Musculoskeletal and Skin Diseases


Dr. Kaplan's research has focused on identifying mechanisms of immune dysregulation, organ damage and premature vascular disease in systemic autoimmunity. More specifically, she investigates how innate immunity (in particular, type I interferons and myeloid cells) promote end-organ damage in systemic lupus erythematosus, rheumatoid arthritis and other systemic autoimmune diseases. Recently, her research has focused on identifying abnormalities of neutrophil subsets and the role of neutrophil extracellular traps (NETs) in lupus and rheumatoid arthritis, both of which may contribute to the development of autoimmune responses and to end-organ damage. Dr. Kaplan also has an interest in identifying novel therapeutic targets that may prevent premature vascular damage in systemic autoimmunity, as well as the role of environmental triggers in the induction of autoimmunity. Moreover, she has led clinical trials to identify mechanisms that reduce blood vessel dysfunction in autoimmune and chronic inflammatory disorders.

The page was last updated on Thursday, May 13, 2021 - 9:52am