Three (Formerly) Blind Mice: Reprogramming Tissues To Be Young Again
David A. Sinclair, Ph.D., A.O. is a Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School. He is best known for his work on understanding why we age and how to slow its effects. He obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995. He worked as a postdoctoral researcher at M.I.T. with Dr. Leonard Guarente where he co discovered a cause of aging for yeast as well as the role of Sir2 in epigenetic changes driven by genome instability. In 1999 he was recruited to Harvard Medical School where he has been teaching aging biology and translational medicine for aging for the past 16 years. His research has been primarily focused on the sirtuins, protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction (CR) with associated interests in chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, and cancer.
Dr. Sinclair will present his very new research on mice, providing intriguing evidence that innovative gene therapy techniques could someday roll back the biological clock of age-related vision loss. This research was conducted with support from the National Institute on Aging and the National Eye Institute and published recently in Nature. The Sinclair lab was the first to identify a role for NAD biosynthesis in the regulation of lifespan and first showed that sirtuins are involved in Caloric Restrictions (CR’s) benefits in mammals and identified the first small molecules that activate sirtuin (silent mating type information regulation 2 homolog) (1 SIRT1) (STACs). His lab also is working on epigenetic changes as a driver of aging and the use of reprogramming factors to reset the age of cells and tissues.
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