Three (Formerly) Blind Mice: Reprogramming Tissues To Be Young Again
Dr. Sinclair will present his very new research on mice, providing intriguing evidence that innovative gene therapy techniques could someday roll back the biological clock of age-related vision loss. This research was conducted with support from the National Institute on Aging and the National Eye Institute and published recently in Nature. The Sinclair lab was the first to identify a role for NAD biosynthesis in the regulation of lifespan and first showed that sirtuins are involved in Caloric Restrictions (CR’s) benefits in mammals and identified the first small molecules that activate sirtuin (silent mating type information regulation 2 homolog) (1 SIRT1) (STACs). His lab also is working on epigenetic changes as a driver of aging and the use of reprogramming factors to reset the age of cells and tissues.
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