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Diabetes Health Disparities: Biology, Race, or Racism

September 29, 2021 - 3:00pm to 4:00pm
Sherita Hill Golden, M.D., John Hopkins Medicine

The author of more than 180 articles, Dr. Golden’s epidemiological research interests focus on two areas: (1) endogenous sex hormones as risk factors for CVD, type 2 diabetes, and insulin resistance in post-menopausal women and (2) mental health complications of diabetes and the biological, hormonal, and behavioral factors that might explain these associations.

Creating Healthy Longevity: A Basis for a Third Demographic Dividend for Society

October 6, 2021 - 3:00pm to 4:00pm
Linda Fried, M.D. , Columbia University Medical Center

Dr. Linda P. Fried, MD, MPH, is a global leader in the fields of epidemiology and geriatrics who has dedicated her career to the science of healthy aging and longer health span for all, and creating the knowledge needed for transition to a world where greater longevity benefits people of all ages. An internationally renowned scientist, she has authored over 500 peer-reviewed articles and chapters. Dr.

Neural Representations of Social Homeostasis

October 13, 2021 - 3:00pm to 4:00pm
Kay Tye, Ph.D., Salk Institute

Kay Tye’s lab seeks to understand the neural-circuit basis of emotion that leads to motivated behaviors such as social interaction, reward-seeking and avoidance. Her lab employs a multidisciplinary approach including cellular-resolution recordings, behavioral assays and optogenetics, a technique that activates certain cells with light, to find mechanistic explanations for how these emotional and motivational states influence behavior in health and disease.

Evolutionary Dynamics of SARS-CoV-2

October 20, 2021 - 3:00pm to 4:00pm
Trevor Bedford, Ph.D., Fred Hutch

Dr. Trevor Bedford uses powerful computers and complex statistical methods to study the rapid spread and evolution of viruses, including those that cause COVID-19, influenza, Ebola and Zika. Data gathered from these processes help researchers develop successful strategies for monitoring and controlling infectious diseases. His visual representations of viral family trees are used to show how the fate of dangerous outbreaks is often determined by the genetics of the infectious agent, human behavior and geography. Dr.

Wound Repair: Dealing with Life's Little Traumas

November 3, 2021 - 3:00pm to 4:00pm
Susan Parkhurst, Ph.D., Fred Hutch

Dr. Susan Parkhurst studies the cytoskeleton, the cell’s internal framework. The cytoskeleton is a dynamic structure, constantly forming and breaking down to meet the cell’s changing needs, including changes in shape and movement. Problems with building and deconstructing the cytoskeleton arise in many human diseases. Wound healing, in which cells move to fill a gap, and the organization of the nucleus, the cell’s DNA storeroom, rely on the cytoskeleton. Dr. Parkhurst studies its roles in these normal conditions and what goes wrong in cancer cells.

A Vision Engaging Pharmacokinetic Strategies to Treat Substance Abuse Disorders and Overdose

November 10, 2021 - 3:00pm to 4:00pm
Kim Janda, Ph.D., Scripps Research

Our work encompasses the following areas: the development of methods for the detection of and protection against chemical/biological warfare agents, the preparation of combinatorial chemical libraries, the design/synthesis and evaluation of catalytic antibodies and enzyme inhibitors, solid-phase organic synthesis, antibody/peptide phage display libraries, the application of immunopharmacotherapy in the treatment of drug addiction and cancer, methods of prevention and treatment of obesity, diagnostic and therapeutic strategies towards neglected tropical diseases, and investigation and develo

Blood Stem Cell Clonality and the Niche

November 17, 2021 - 3:00pm to 4:00pm
Leonard Zon, M.D., Harvard Medical School

Research in the Zon lab focuses on the developmental biology of hematopoiesis and cancer. Over the past five years, they have collected over 30 mutants affecting the hematopoietic system. Some of the mutants represent excellent animal models of human disease. For instance, the isolation of the ferroportin iron transporter was based on a mutant zebrafish and subsequently was shown to be mutated in patients with iron overload disorders. The mutants also represent interesting key regulatory steps in the development of stem cells.

Reconstruction of the Pathophysiology of Chronic Pain from Genome-wide Studies

December 1, 2021 - 3:00pm to 4:00pm
Luda Diatchenko, M.D., Ph.D. , McGill University

The Diatchenko lab investigates the psychological, molecular, cellular, and genetic pathways that mediate both acute and persistent pain states. Their primary goal is to identify the critical elements of human genetic variability contributing to pain sensitivity and pathophysiological pain states that will enable individualized treatments and therapies. Other related research endeavors include molecular hierarchy of functional SNPs (single-nucleotide polymorphisms) and SNP-depend regulation of gene expression, underlying molecular pain signaling.

Advancing Therapies for Neurofibromatosis Type 1 (NF1): Lessons Learned from Every Patient

December 8, 2021 - 3:00pm to 4:00pm
Brigitte Widemann, M.D., National Institutes of Health, National Cancer Institute

Dr. Brigitte Widemann is a pediatric oncologist with the primary interest of developing effective therapies for children and adults with genetic tumor predisposition syndromes, such as neurofibromatosis type 1 (NF1), and rare solid tumors through innovative clinical trial design. Dr. Widemann currently serves as the head of the Pharmacology & Experimental Therapeutics Section and as Chief of NCI’s Pediatric Oncology Branch. Anticancer drug discovery and development are moving towards a more rational and targeted approach.

Cytokine Signaling: The More Things Change, the More They Stay the Same

December 15, 2021 - 3:00pm to 4:00pm
John O'Shea, M.D., National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Cytokines are critical for host defense but are also key factors in immune and inflammatory diseases. Innate and adaptive lymphocytes, including T cells, are important selective producers of cytokines, and it is through the production of these that immune responses work together to eliminate microbial pathogens. Host defense against pathogenic microorganisms requires this elegant means of communication between innate and adaptive arms of the immune system.

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The page was last updated on Thursday, September 30, 2021 - 11:53am