Current Lecture Season
All lectures are viewable live at http://videocast.nih.gov and then later archived there.
Additionally, the following lectures will be in person at Lipsett Amphitheater to a limited audience: May 4 (Namandjé Bumpus), May 11 (John Kuriyan), May 25 (Olufunmilayo Olopade), June 7 (Yishi Jin), June 8 (Yakeel Quiroz), June 15 (Gillian Griffiths), and June 29 (Ileana Cristea). Contact WALSoffice@od.nih.gov if you are interested in attending.
Elucidation and Pharmacological Targeting of Non-oncogene Dependencies at the Single-Cell Level
We have developed network-based methodologies for the systematic identification, validation, and pharmacological targeting of a new class of therapeutic targets. These targets comprise Master Regulator proteins, whose concerted activity within a Regulatory Checkpoint module is responsible for the mechanistic implementation and maintenance of cell transcriptional state, in both transformed and non-transformed cells.
Single-Molecule Studies of Homologous Recombination
Homologous recombination (HR) is essential for maintenance of genome integrity. Rad51 paralogs fulfill a conserved but undefined role in HR, and their mutations are associated with increased cancer risk in humans. We have used single-molecule imaging to reveal that the Saccharomyces cerevisiae Rad51 paralog complex Rad55-Rad57 promotes assembly of Rad51 recombinase filament through transient interactions, providing evidence that it acts like a classical molecular chaperone. Srs2 is an ATP-dependent anti-recombinase that downregulates HR by actively dismantling Rad51 filaments.
CANCELLED — Translating Studies of HIV Immunity to SARS-CoV-2
CANCELLED
Turning Genes into Medicines: Challenges in the Development of Gene Therapeutics
The first approved gene therapy in the Western world, alipogene tiparvovec, gained conditional approval by the European Medicines Agency in 2012. This lecture will review the progress of gene therapy since, including currently approved products and those in late-stage testing. Hurdles to approval, including the need to build regulatory infrastructure, and in some cases, the need to develop novel endpoints for diseases never before treated, will be discussed.
Reconstruction of the Pathophysiology of Chronic Pain from Genome-wide Studies
The molecular pathophysiology of chronic pain is largely unknown. The genetic and molecular studies of human pain can nevertheless provide critical insights into pathophysiological mechanisms of pain "chronification," the process of transient pain progressing into persistent pain. Genome-wide “omics” approaches allow a whole human genome scan that is hypothesis-free and permit systematic use and integration of multiple genome-wide datasets, resulting in unbiased interpretation of data. In this talk, Dr.
Evolving Adaptive Reproductive Capacity: A Systems Approach Using Drosophila Models
Key Lecture Points: Adult reproductive fitness traits can be regulated by local cell behaviour decisions during early development. No single “smoking gun” gene regulatory network regulates complex reproductive trait. Environment-sensing molecular mechanisms may link heritability and plasticity. Establishing null expectations for evolutionary changes helps focus the search for adaptive mechanisms. Nothing explains everything: broad taxon sampling is still important
How Did Birds Evolve the Capacity to Vocalize?
Birds "sing" using a unique vocal organ called the syrinx. It is an example of the evolution of a novel structure. We have explored the genetic pathways underlying the embryonic formation of the syrinx to understand its morphogenesis and to understand how this adaptation arose.
POSTPONED TILL FALL — Mutant p53 Activities in Mouse Tumor Models
This lecture has been rescheduled for October 12, 2022.
POSTPONED TILL FALL — RNA Splicing, Chromatin Modification, and the Coordinated Control of Gene Expression
This lecture is postponed till fall 2022.
POSTPONED TILL FALL — Knowing Right From Wrong (Protein Conformation): The Challenging Choices of (Molecular) Chaperones
This lecture has been rescheduled for September 21, 2022.
Pages
The page was last updated on Monday, May 2, 2022 - 4:24pm
