Current Lecture Season
All lectures are viewable live at http://videocast.nih.gov and then later archived there.
Additionally, the following lectures will be in person at Lipsett Amphitheater to a limited audience: May 4 (Namandjé Bumpus), May 11 (John Kuriyan), May 25 (Olufunmilayo Olopade), June 7 (Yishi Jin), June 8 (Yakeel Quiroz), June 15 (Gillian Griffiths), and June 29 (Ileana Cristea). Contact WALSoffice@od.nih.gov if you are interested in attending.
The Fair laboratory focuses on mechanisms and principles that underlie the developing brain. The majority of this work uses functional MRI and resting state functional connectivity MRI to assess typical and atypical populations. Dr. Fair is the co-director of the new Masonic Institute for the Developing Brain.
(This will be a hybrid lecture, on Tuesday, in person at Lipsett Amphitheather and on NIH VideoCast.) Neurons employ many mechanisms to sustain function throughout lifetime. Following traumatic injury to axons, neurons often initiate complex responses to regenerate and repair. To understand the underlying mechanisms, we established in vivo laser axotomy assay in C. elegans. Using live imaging, we characterized rapid cellular dynamics following axon injury. We carried out large-scale genetic screening and discovered several molecular pathways.
Charting the Path for Alzheimer's Prevention with the Colombian Kindred with Autosomal Dominant Alzheimer's Disease
(This will be a hybrid lecture, previously advertised as being on June 22, now June 8 in person at Lipsett Amphitheather and on NIH VideoCast.) We work with an extraordinary kindred of approximately 6,000 individuals in Antioquia, Colombia, which contains roughly 1,200 carriers of a single autosomal-dominant mutation (PSEN1 E280A). These carriers are expected to develop early onset Alzheimer’s Disease, with almost 100% certainty, and have a well-characterized disease course, with mild cognitive impairment (MCI) occurring at a median age of 44, and dementia at 49.
My presentation will focus on the cell biology that underlies the remarkable ability of cytotoxic T lymphocytes to act as serial killers, with individual cells providing sustained killing in response to cancer or virally infected targets. I’ll describe a screen that picked up genes that are required for sustained killing and revealed an unexpected role for mitochondria as homestatic regulators of CTL killing. I’ll then describe work by a former NIH-OxCam student that reveals an (again unexpected) role for transcription during killing.
(This will be a hybrid lecture, in person at Lipsett Amphitheather and on NIH VideoCast.) Organelle remodeling is an essential component of all human virus infections. Viruses rely on the biological processes partitioned within organelles for their infectious cycles. Likewise, host cells require organelles to detect and combat pathogen invasion. Here, we integrate molecular virology, super-resolution microscopy, and proteomics to characterize organelle structure-function relationships in the context of viral infections.
The page was last updated on Monday, May 2, 2022 - 4:24pm