Florence Mahoney Lecture on Aging
Sponsored by the National Institute on Aging, the series recognizes Mrs. Mahoney’s lifetime commitment to medical research and its benefits to people worldwide. Florence Stephenson Mahoney is widely known for her dedicated efforts in shaping national health science policy, particularly with respect to aging.
Charting the Path for Alzheimer's Prevention with the Colombian Kindred with Autosomal Dominant Alzheimer's Disease
(This will be a hybrid lecture, previously advertised as being on June 22, now June 8 in person at Lipsett Amphitheather and on NIH VideoCast.) Dr. Quiroz is Associate Professor in the Departments of Psychiatry and Neurology at Massachusetts General Hospital and Harvard Medical School, Boston, MA. She currently serves as Director of the MGH Familial Dementia Neuroimaging Lab, and Multicultural Alzheimer’s Prevention Program (MAPP).
For her April 7 lecture, Dr. Brunet will present her lab’s work on the regulation of brain aging and rejuvenation, notably the role of the immune system. She will discuss how her lab pioneered the naturally short-lived African killifish as a new model to identify principles underlying vertebrate aging.
Evidence has indicated that the cerebrovasculature is an important target and that brain endothelial cells show prominent age-related transcriptional changes in response to plasma. Scientists also have discovered that plasma proteins are taken up broadly into the brain and that this process varies between individual endothelial cells and with aging. Researchers are currently exploring the relevance of these findings for neurodegeneration.
In addition to serving as director of NCI, Dr. Sharpless continues his research in understanding the biology of the aging process that promotes the conversion of normal self-renewing cells into dysfunctional cancer cells. Dr. Sharpless has made seminal contributions to the understanding of the relationship between aging and cancer, and in the preclinical development of novel therapeutics for melanoma, lung cancer, and breast cancer.
Dr. Mucke’s research focuses on conditions that cause cognitive deficits, behavioral abnormalities and other major neurological alterations, including aging-related dementias, epilepsy and neuropsychiatric disorders. He uses transgenic mouse models and neural cultures to dissect the pathogenic pathways that lead from genetic and environmental risk factors to neurological abnormalities at the molecular, cellular, network and behavioral level. Experimental models are also used to develop and evaluate novel treatment strategies.
Research in Dr. Wagers’s lab seeks to discover fundamental principles that govern tissue aging and determine stem cell function in organ regeneration and degenerative disease. These efforts build upon novel discoveries and unique experimental models, which are defining the cellular and molecular networks that control muscle regenerative activity and uncovering common signals delivered via the bloodstream that can reverse the effects of aging across tissues.
Dr. Singleton's talk will focus on the most effective route to testing disease-modifying therapies in neurodegenerative disease earlier in the disease process, with a particular focus on Parkinson disease. He will discuss attempts to make headway in identifying at-risk patients as early as possible in the disease process, when interventions may be most effective.
A multiscale biology approach for dissecting the complex processes underlying aging and aging related phenotypes
The annual Mahoney Lecture is named in honor of Florence Stephenson Mahoney (1899–2002), who devoted the last half of her life to successfully advocating for the creation of the National Institute on Aging and increased support for NIH. During his lecture, Dr. Schadt will focus on the integration of the digital universe of information to better diagnose, treat, and prevent human disease. The lecture will feature the work of Dr.
Aging is a crucial risk factor in a constellation of human diseases, including cancer and neurodegenerative diseases. Along with other risk factors such as environmental exposures, diet, behavior, and heredity, these risks can be understood through their impact on the epigenetic landscape in ways that ultimately lead to the burden of disease. Among these risks, aging had been regarded as fixed, but current thinking holds that aging is plastic and its pace can be slowed or even reversed. Dr.
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