Rolla E. Dyer Lecture
Established in 1950 in honor of former NIH Director Rolla E. Dyer, M.D., a noted authority on infectious diseases, this lectureship, now part of the Wednesday Afternoon Lecture Series, features internationally renowned researchers who have contributed substantially to medical as well as biological knowledge of infectious diseases. The Dyer Lecture is the oldest continuous lecture series at the NIH.
(This will be a hybrid lecture, in person at Lipsett Amphitheather and on NIH VideoCast.) Antiretroviral therapy has markedly reduced morbidity and mortality for persons living with human immunodeficiency virus (HIV). Individual tailoring of antiretroviral regimens has the potential to further improve the long-term management of HIV through the mitigation of treatment failure and drug-induced toxicities.
Increasing prevalence and severity of multi-drug-resistant bacterial infections require novel management strategies. One possible strategy is a renewed approach to ‘phage therapy,’ where these administered viruses not only kill the target bacteria, but also predictably select for phage resistance that reduces virulence and/or increases antibiotic sensitivity (evolutionary trade-offs).
Dr. Cooper's research at Johns Hopkins University has focused on the crisis of inequity in medical care. Dr. Cooper was one of the first scientists to document disparities in the quality of relationships between physicians and patients from socially at-risk groups. A recipient of a MacArthur "Genius" Award, she has designed innovative interventions targeting physicians' communication skills, patients' self-management skills, and healthcare organizations' ability to address needs of populations experiencing health disparities.
Research in the Ghedin Lab meets at the interface of microbiology, genomics, and systems biology. Projects touch on the extent of intra- and inter-host microparasite (viruses and bacteria) diversity within the context of transmission and virulence, and parse the relationship between microbial ecology in the respiratory tract and disease progression.
The Fitzgerald lab is focused on understanding the molecular mechanisms controlling the inflammatory response. We are interested in determining how the immune system discriminates between pathogens, resident microflora and host molecules to both protect the host from infection and avoid damaging inflammatory diseases. We employ multifaceted approaches including immunology, biochemistry, molecular biology and genetics to understand these mechanisms.
Dr. Belkaid work explores the field of immune regulation and has defined fundamental mechanisms that regulate tissue homeostasis and host immune responses. Her work uncovered key roles for the commensal microbiota and dietary factors in the maintenance of tissue immunity and protection to pathogens.
Current research interests are focused on characterization of the structure and function of the microbial communities that are found in the human environment, as part of the NIH-funded Human Microbiome Project, including projects specifically focused on obesity, metabolic syndrome, inflammatory bowel disease, the interactions between the human immune response and the gut microbiome, and the impact of probiotics on the structure and function of the intestinal microbiome.
The Virgin lab issues at the interface between virology and immunology, working from the hypothesis that viruses manipulate the immune response using immunoevasive gene products as the immune response attempts to eradicate the virus. Please see the informative and amusing animated video at http://pathology.wustl.edu/labs/virgin.
Research over the past two decades has led to the fundamental understanding that initiation of immune responses to infectious microorganisms relies on pathogen recognition by innate microbial sensors, collectively known as pattern recognition receptors (PRRs). PRRs fall into several families, each of which recognizes distinct pathogen-associated molecular patterns (PAMPs). Stimulating PRRs results in transcriptional activation of genes involved in innate defense as well as those that activate antigen-presenting cells for successful priming of “adaptive” T- and B-cell responses.
The page was last updated on Monday, May 2, 2022 - 12:36pm